Clinical significance of quantitative immunohistology in labial salivary glands for diagnosing Sjögren's syndrome
نویسندگان
چکیده
منابع مشابه
Observations of Nerve Terminals in Human Labial Salivary Glands
The existence of a motor innervation to the secretory and myoepithelial elements of salivary glands has been supported amply by physiological and pharmacological studies extending over a century (reviewed in Babkin, 1950 ; Emmelin, 1967) . However, the exact morphological nature of this innervation at the acinar level is less well established, and has been the subject of several conflicting rep...
متن کاملDetection of AA-type amyloid protein in labial salivary glands.
OBJECTIVES Among the diverse forms of amyloidosis, secondary type is the most frequent one. Diagnosis of amyloid deposition is based on the identification of the fibrillary protein amyloid by means of Congo Red (CR) or crystal violet (CV) stains, but these techniques do not differentiate between the different types of amyloid fibrils. The aim of this study was to identify by immunofluorescence ...
متن کاملImmunoglobulin-containing cells in normal human labial salivary glands.
The distribution of immunoglobulin-containing cells within 8 normal human labial salivary glands was studied using an immunoperoxidase technique. Cell counts revealed that IgA-containing cells pre-dominated in all specimens and that the mean percentage class ratios for IgG:IgA:IgM:IgD cells were 4:92:3:1. IgE cells were rare and only detected in one gland. The density of IgA cells (191 cells/mm...
متن کاملSelective localization of T helper subsets in labial salivary glands from primary Sjögren's syndrome patients
The aim of this study was to investigate the initiation and progression of autoimmune damage in the lesions of labial salivary glands (LSGs) from primary Sjögren's syndrome (SS) patients by examining the selective localization of T helper (Th) subsets such as Th1, Th2, Th17 regulatory T cells (T(regs)) and follicular T helper cells (Tfh). The expression of cytokines and transcription factors as...
متن کاملAcinar epithelial cell laminin-receptors in labial salivary glands in Sjögren's syndrome.
OBJECTIVE To analyze the epithelial cell-basement membrane attachment, in particular in the secretory end pieces (responsible for secretion of saliva) and in Sjögren's syndrome (SS) characterized by acinar cell failure. METHOD Immunohistochemistry with laminin receptor chain-specific monoclonal antibodies to integrin (Int) subunits, Lutheran blood group antigen and alpha-dystroglycan. RESUL...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Rheumatology
سال: 2005
ISSN: 1462-0332,1462-0324
DOI: 10.1093/rheumatology/kei191